- Type: Litchi Seed Extract
- Form: Powder
- Part: Seed
- Packaging: Can
- Place of Origin: Japan
Packaging & Delivery
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SpecificationsLitchi Seed Extract is expected to inhibit enzymes involving in the degradation of collagen, elastin and hyaluronic acid.
Moisturing, Whitening and Anti-wrinkles
Food and Cosmetics Ingredient
Litchi Seed Extract, which was developed as a cosmeceutical food, is expected to inhibit enzymes involving in the degradation of collagen, elastin and hyaluronic acid,thus, to inhibit decreases in collagen, elastin and hyaluronic acid, and maintain the tension and moisture of the skin, preventing wrinkles.
Litchi Seed Extract also eliminates active oxygen (superoxide) and other molecular radicals, which would cause wrinkles, skin aging, and carciogenesis, by acting like superoxide dismutase (SOD), a radical scavenger.
In addition, we newly discovered an amazing function in Litchi Seed Extract, that induces apoptosis in human stomach cancer cells.
Whitening is important from the cosmetic aspect. Dark skin, pigmentation, and spots are caused by melanin. An amino acid, tyrosine, is converted in vivo into dopa by an enzyme tyrosinase, and subsequently into dopa quinone, from which melanin is produced by oxidation. Litchi Seed Extract inhibits tyrosinase, thus, inhibiting melanin formation, so it is expected to promote whitening.
Collagen is present not only in skin, nails, and hair but also in bone stiffness, which has been reported to be useful for preventing osteoporosis, cartilage wear, and rheumatoid arthritis and preventing and improving osteoarthrosis. These disorders are more frequently seen in females, and therefore, we recommend Litchi Seed Extract as food with multiple functions particularly for females.
Components of Litchi Seed Extract
Litchi Seed Extract contains Saponin, Tanin, Leucocyanidin (Flavonoid), Anthocyanin, etc.
Functions of Litchi Seed Extract
Inhibition of Collagenase
Collagen is distributed in the entire dermis of the skin, constituting 90% of the dermis. Collagen maintains appropriate elasticity and strength of the skin. When collagenase, an enzyme, is activated, and collagen is degraded, wrinkles and sagging as aging phenomena of the skin develop. Collagen produced in the body is degraded by collagenase.
Litchi Seed Extract inhibited collagenase at a low concentration, thus, Litchi Seed Extract suggested to inhibit the degradation of collagen.
Collagen Productivity in Normal Human Fibroblasts
It is said that productivities of collagen in human skin starts to decline at around age of 20. It may be possible to maintain elastic and smooth skin if productivities of collagen is recovered.
Litchi Seed Extract increased collagen production in normal human fibroblasts (cells
equivalent to those in humans at the ages when the collagen productivity starts declining).
Inhibition of Elastase
Elastin is distributed in the entire dermis of skin. Tension and elasticity of skin are kept by moderate balance of collagen and elastin and hyaluronic acid. Elastin maintains appropriate elasticity and strength of the skin. When elastase, an enzyme, is activated, and elastin is degraded, wrinkles and sags grow as aging phenomena of skin. Elastin produced in the body is degraded by elastase.
Litchi Seed Extract inhibited elastase at a low concentration, thus, it decreases the degradation of elastin effectively.
Inhibition of Hyaluronidase
Hyaluronic acid is widely distributed in tissues such as skin, synovial fluid, vitreous body, and ligaments. Hyaluronic acid is involved in the adhesion and protection of cells, formation of skin tissue, and the maintenance of the moisture and flexibility of tissue. With a decrease in hyaluronic acid, the skin loses moisture and tension, and develops wrinkles and sagging. Hyaluronic acid is degraded by the enzyme, hyaluronidase.
Litchi Seed Extract inhibited hyaluronidase, thus, it inhibits the degradation of hyaluronic acid.
In the human body, the presence of active oxygen species (O2- radicals) causes cellular damage, which induces cancer and inflammation, and promotes aging. In particular, in the skin, active oxygen is considered to be a cause of spots, freckles, and wrinkles.
Litchi Seed Extract showed SOD-like activity (elimination of active oxygen) and eliminated radicals. Litchi Seed Extract is expected to prevent lifestyle-related diseases caused by active oxygen.
DPPH Radical Quinching Activity
The radical scavenging activity of Litchi Seed Extract was comparable to that of vitamin C.
Inhibition of Tyrosinase
Dullness, darkness, and spots of the skin are caused by melanin. Melanin is formed from dopa quinone that is converted from tyrosine by tyrosinase. Litchi Seed Extract inhibited tyrosinase activity and appears to be applicable to foods for whitening.
This tyrosinase inhibitory activity of Litchi Seed Extract was comparable to that of
Effect on Melanin Formation
Litchi Seed Extract was added to cultured B16 melanoma cells. It was found that 100ppm of the extract surpressed melanin production by 33 percent. It was also found that the extract of seed showed the strongest surpression than the ones of other parts of litchi fruit.
Moisture Retention Test
After direct topical application of samples to skin, moisture retention ability was measured. When only distilled water was applied, the water content returned to the pre-application level after about 25 minutes. On the other hand, moisture was retained for more than 60 minutes after application of Litchi Seed Extract.
Induction of Apoptosis in Human Stomach Cancer Cells by Litchi Seed Extract
Effect of Litchi Seed Extract on induction of Apoptosis was examined in human stomach cancer cells in vitro . Nuclei of stomach cancer cells were stained by DAPI, and observed under fluorescent microscope equipped with a CCD camera. As a result, any change was not found in controls. On the other hand, DNA fragmentation was found by Litchi Seed Extract (arrows). DNA fragmentation was confirmed in electrophoresis as well. The result suggests that Litchi Seed Extract induced DNA fragmentation on cell in a dose-dependent manner.
Inhibitoion of Aldose Reductase
Aldose reductase exists in various tissues where diabetes complications ware found, such as in crystal lenses, retinas, peripheral nerves, kidneys, and blood vessels. Aldose reductase is involved in the occurrence and clinical conditions of diabetes. Inhibitory effect of Litchi Seed Extract on aldose reductase was examined using purified aldose reductase.
As shown in following figure, 100 μg/mL of Litchi Seed Extract surpreessed (57.5%) aldose reductase activity. As we previously mentioned, Litchi Seed Extract showed anti-oxidative activity in internal body. Therefore, Litchi Seed Extract is possibly prevents complications that would occur as diabetes progresses via aldose reductase inhibition.